Itching that occurs in chronic renal failure (uremia) is a very disabling symptom.

Now we will see treatments with natural products for uremic itching, its causes

and used therapies.


Uremic itching, especially when it's untreatable, is a symptom with devastating impact

on the psycho-physical state of patient. It affects about half of patients with uremia,

most often spread entire surface of the body.  It can be followed by lack of strength,

state of restlessness up to depression and is associated with increased risk  of death.


Uremic itching is one of the most frequent, frustrating and potentially disabling

manifestations of skin disease in chronic uremic.


It affects over 50% of patients, whether they are treated with extracorporeal or

peritoneal dialysis.  It greatly affects quality of sleep. Patients with itchy uremic

report that they cannot sleep at night and consequently experience drowsiness during

the day. This disability can be resolved with use of natural remedies for uremic itching.


There is correlation between nerve pathways that cause itching and those responsible

for pain. In fact, as for pain, a group of type C fibers responsible for conduction of this

stimulus was identified for itching. They are able to activate medullary neurons which

then transmit signal to thalamic area.


Type C nerve fibers are present in the deep layers of epidermis or in the dermo-epidermal

junction of skin, where they interact with mast cells.

They influence production of itching by releasing vasoactive peptides like histamine, IL-2,

some proteases and TNF.


Therapies usually used initially use polymethylmethacrylate membranes during dialysis.

Then, skin emollients or capsaicin creams are used (which cannot be applied to large

surfaces due to irritating effect). Subsequently, systemic treatments are carried out with

use of ultraviolet B rays (with potential carcinogenic effect on the skin).


Not so with natural solutions for itching in kidney failure.

Anticonvulsant drugs like gabapentin can also be used with possible side effects:

                                   1) Neurotoxicity up to coma.

                                   2) Agitation.

                                   3) Exophthalmos.

                                   4) Psoriasis.

                                   5) Pancreatitis). 


Moreover, results are unsatisfactory if, as already talk, more than half of the patients

continue to have itching, in addition to the heavy side effects


But, natural cures for uremic itching can be performed due to their effectiveness and

absence of side effects thanks to action of natural products like Calendula Officinalis

and Rhodiola rosea which have an anti-inflammatory, anti free radical and soothing



There are also other natural substances (flavoproteins and other coenzymes such as NAD

and NADP) that contribute to restoration of mast cell metabolism with

the consequent restoration of physiological vasoactive peptides release. Therefore, natural

solutions are possible and advisable in exclusive patients interest.