COVID 19, Natural Cures

Mast cells represent the backbone of immune system. Below we see the

implications that Covid 19 has with mast cells and the natural cures that

can be implemented.

The hallmark of COVID-19 is the cytokine storm, with high levels of interleukin-6

(IL-6), IL-1β, tumor necrosis factor alpha (TNF-α), i.e. proinflammatory cytokines,

released in excess by activated mast cells, which cause severe pneumonia and

neurological disorders, including stroke, disruption of blood brain barrier, and damage

to endothelial cells in the brain.

COVID-19, in its most aggressive form, is a hyperinflammatory syndrome, due to

both the excessive production of proinflammatory cytokines and the dysfunction

of the immune response. In fact, despite the very broad spectrum of tissues that

CoV-2 can infect, the multiorgan dysfunction that characterizes patients with severe

COVID-19 depends, above all, on an out-of-control immune response, rather than

on direct tissue damage due to viral infection. 

Inflammatory response of the lung, which occurs after exposure to SARS-CoV-2,

is due to a series of inflammatory immune cells and lung cells, like bronchial epithelial

cells, endothelial cells and fibroblasts.

Bronchial epithelial cells activated by SARS-CoV-2 cause an increase in pro-inflammatory

cytokines and induction of mast cell differentiation. But the inflammation can subside

by using natural solutions for Covid 19.

Histamine and IL-1 are responsible for the onset of the pulmonary inflammatory reaction.

Furthermore, IL-1 together histamine can cause a sharp increase in IL-1 levels and,

consequently, a higher degree of inflammation.

WHAT are the RELATIONSHIP between COVID and the IMMUNE SYSTEM

Mast cells are granulocytes, which are white blood cells with granules

containing a number of powerful chemicals like histamine, serotonin, and

protein-digesting enzymes such as chymases and tryptases. Their number 

in the body is nothing short of impressive: in fact, it is between

7,000 and 12,000 per cubic millimeter of body tissue.

This makes us understand how their irregular functioning can trigger

phenomena that can also life threatening. These cells also influence vascular

tone and permeability, through the vasoactive content of their granules.

By doing so, they can induce tissue hypoxia and cause damage to both the

tissue and the vascular structure.

The SARS-CoV-2 virus is an infectious agent found in some animals and today

also in humans: it has caused a pandemic infection with acute respiratory

distress syndrome with severe lung damage.

WHAT is the ROLE of MASTOCYTES in COVID

Pathology associated with pandemic infection is linked to an 

excessive response of mast cells activated by the virus. But the excessive

response of activated mast cells can be brought back to normal with a natural

remedy for Covid. 

In this pathological environment, mast cell activation therefore causes an

excessive release of histamine, proteases, cytokines, chemokines and VEGF, 

which are involved in the inflammatory response. But, if the mast cells have

a normal and not unregulated metabolism, the stimulation caused by the

virus is counterbalanced by the release of anti-inflammatory cytokines,

wich are protective.

Furthermore, histamine increases the formation of IL-6, which is a proinflammatory

cytokine and since activated mast cells produce a lot of histamine in inflammatory

reactions, this vasoactive amine amplifies the inflammatory process in the

SARS-CoV-infected lung. 

Then, there is also an increased production of reactive oxygen species, i.e. free radicals

and these also cause the production of pro-inflammatory cytokines.

WHAT NATURAL TREATMENTS for COVID

However, a natural cure for Covid 19, based on strengthening the immune system, can be

implemented in a natural way, thanks to the action of herbal substances, like Rhodiola rosea

and Calendula officinalis, which have anti-free radical, anti-inflammatory, antiplatelet

properties.

Together with other natural substances, like flavoproteins and coenzymes, they

contribute effectively and harmlessly to the restoration of mast cell metabolism.

All this achieves the rebalancing of the altered body environment and the restoration of

optimal conditions of the immune system.