COVID 19, Immune System and Mastcells

Mast cells represent the backbone of immune system. Below we see the implications that Covid 19 has with mast cells and the natural cures that can be implemented.

 

Mast cells are granulocytes, which are white blood cells with granules containing a number of powerful chemicals like histamine, serotonin, and protein-digesting enzymes such as chymases and tryptases. Their number in the body is nothing short of impressive: in fact, it is between 7,000 and 12,000 per cubic millimeter of body tissue. This makes us understand how their irregular functioning can trigger phenomena that can also life threatening. These cells also influence vascular tone and permeability, through the vasoactive content of their granules. By doing so, they can induce tissue hypoxia and cause damage to both the tissue and the vascular structure.

 

The SARS-CoV-2 virus is an infectious agent found in some animals and today also in humans: it has caused a pandemic infection with acute respiratory distress syndrome with severe lung damage.

 

Pathology associated with pandemic infection is linked to an excessive response of mast cells activated by the virus. But the excessive response of activated mast cells can be brought back to normal with a natural cure for Covid

 

The hallmark of COVID-19 is the cytokine storm, with high levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor alpha (TNF-α), i.e. proinflammatory cytokines, released in excess by activated mast cells, which cause severe pneumonia and neurological disorders, including stroke, disruption of blood brain barrier, and damage to endothelial cells in the brain.

 

COVID-19, in its most aggressive form, is a hyperinflammatory syndrome, due to both the excessive production of proinflammatory cytokines and the dysfunction of the immune response. In fact, despite the very broad spectrum of tissues that CoV-2 can infect, the multiorgan dysfunction that characterizes patients with severe COVID-19 depends, above all, on an out-of-control immune response, rather than on direct tissue damage due to viral infection. 

 

Inflammatory response of the lung, which occurs after exposure to SARS-CoV-2, is due to a series of inflammatory immune cells and lung cells, like bronchial epithelial cells, endothelial cells and fibroblasts. Bronchial epithelial cells activated by SARS-CoV-2 cause an increase in pro-inflammatory cytokines and induction of mast cell differentiation.

 

Histamine and IL-1 are responsible for the onset of the pulmonary inflammatory reaction. Furthermore, IL-1 together histamine can cause a sharp increase in IL-1 levels and, consequently, a higher degree of inflammation.

 

In this pathological environment, mast cell activation therefore causes an excessive release of histamine, proteases, cytokines, chemokines and VEGF, which are involved in the inflammatory response. But, if the mast cells have a normal and not unregulated metabolism, the stimulation caused by the virus is counterbalanced by the release of anti-inflammatory cytokines, wich are protective. And this can be achieved by using natural cures for Covid 19.

 

Furthermore, histamine increases the formation of IL-6, which is a proinflammatory cytokine and since activated mast cells produce a lot of histamine in inflammatory reactions, this vasoactive amine amplifies the inflammatory process in the SARS-CoV- infected lung. Then, there is also an increased production of reactive oxygen species, i.e. free radicals and these also cause the production of pro-inflammatory cytokines.

 

However, a natural cure for Covid 19, based on strengthening the immune system, can be implemented in a natural way, thanks to the action of herbal substances, like Rhodiola rosea and Calendula officinalis, which have anti-free radical, anti-inflammatory, antiplatelet properties, nourishing the blood vessel wall. Together with other natural substances, like flavoproteins and coenzymes, they contribute effectively and harmlessly to the restoration of mast cell metabolism. All this achieves the rebalancing of the altered body environment and, therefore, the prevention and treatment of Covid 19 with natural products.