HEADACHE and MIGRAINE by DAO (Diaminoxidase) Deficiency

A weak activity of Diaminoxidase enzyme (DAO) makes body unable to fight histamine excess. It remains active in intestine and can cause

headaches. Let's see natural cures for headache or migraine by DAO deficiency and precautions for carrying out DAO test.


Excess of histamine, which is a neural transmitter, causes vessels modifications that cause inflammation and can lead to migraine attack. Many

migraine patients have deficiency in activity of  DAO enzyme. DAO activity is not always related to the concentration of enzyme itself. Analysis of its

concentration in the blood is not always useful for finding cause of migraine. DAO test evaluates activity of DAO enzyme in the blood using

immunoenzymatic technique. It's aimed to people who suffer from frequent headaches and / or migraines.


Histamine increase in the circulation also involves mast cells. Decrease in their efficiency prevents accumulation in them of histamine produced, as

normally happens, thus allowing increase in circulating level of histamine in the blood. The finding of a reduction in the DAO enzyme, as a triggering

factor for migraine, allows an effective preventive treatment of the disease. The result is improvement in patients quality of life. Natural cures and

remedies for DAO deficiency migraine are possible. They enhance activity of mast cells, thus eliminating the risk of headache onset.


Recommendations for the DAO survey are as follows: carry out the exam in 24-72 hours following migraine crisis and be fasting for 8 hours.

Temporarily stop taking drugs decreasing presence of DAO enzyme in the blood. Such drugs are anti-inflammatory, antihistamines, antidepressants,

diuretics, antibiotics, prokinetics (drugs used for gastroesophageal reflux), mucolytics, neuroleptics.

It's not recommended to perform this test during pregnancy, because placenta produces DAO enzyme. This, in fact, is one of the causes why migraine

attacks decrease during pregnancy.


As therapy, it's recommended taking DAO enzymes before meals or diets with histamine-free foods. This is it to increase the body's DAO content or

reduce histamine taken in the diet. However, these measures don't solve problem.


But natural cures for DAO deficiency migraine are possible with natural products such as Vitis vinifera and Rhodiola rosea. They have anti-free

radical, anti-inflammatory, anti-aggregating action. Then, there are natural organic substances, such as flavoproteins and coenzymes, which

contribute effectively and not harmful to restoration of mast cell metabolism. This produces reintegration of production and storage of neural

transmitters that cause headache. Last, but not least, studies found that 95% of people with headaches or migraines have more or less remarkable

deficiency of DAO. An equal percentage of people with various forms of headache who use Biocephal greatly benefit from this natural supplement.