Itching that occurs in chronic renal failure (uremia) is a very disabling symptom. Now we will see treatments with natural products for uremic

itching, its causes and used therapies.


Uremic itching, especially when it's untreatable, is a symptom with devastating impact on the psycho-physical state of patient. It affects about half

of patients with uremia, most often spread entire surface of the body.  It can be followed by lack of strength, state of restlessness up to depression

and is associated with increased risk  of death. Uremic itching is one of the most frequent, frustrating and potentially disabling manifestations of

skin disease in chronic uremic.


It affects over 50% of patients, whether they are treated with extracorporeal or peritoneal dialysis. It greatly affects quality of sleep. Patients with

itchy uremic report that they cannot sleep at night and consequently experience drowsiness during the day. This disability can be resolved with use of

natural remedies for uremic itching.


There is correlation between nerve pathways that cause itching and those responsible for pain. In fact, as for pain, a group of type C fibers

responsible for conduction of this stimulus was identified for itching. They are able to activate medullary neurons which then transmit signal to

thalamic area.


Type C nerve fibers are present in the deep layers of epidermis or in the dermo-epidermal junction of skin, where they interact with mast cells.

They influence production of itching by releasing vasoactive peptides like histamine, IL-2, some proteases and TNF.


Therapies usually used initially use polymethylmethacrylate membranes during dialysis. Then, skin emollients or capsaicin creams are used

(which cannot be applied to large surfaces due to irritating effect). Subsequently, systemic treatments are carried out with use of ultraviolet B rays

(with potential carcinogenic effect on the skin).


Anticonvulsant drugs like gabapentin can also be used with possible side effects:

                                   1) Neurotoxicity up to coma.

                                   2) Agitation.

                                   3) Exophthalmos.

                                   4) Psoriasis.

                                   5) Pancreatitis). 

Moreover, results are unsatisfactory if, as already talk, more than half of the patients continue to have itching, in addition to the heavy side

effects. Not so with natural remedies for itching in kidney failure.


But, natural cures for uremic itching can be performed due to their effectiveness and absence of side effects thanks to action of natural

products like Calendula Officinalis and Rhodiola rosea which have an anti-inflammatory, anti free radical and soothing action. There are also

other natural substances (flavoproteins and other coenzymes such as NAD and NADP) that contribute to restoration of mast cell metabolism with

the consequent restoration of physiological vasoactive peptides release. Therefore, a natural remedy for uremic itching is possible and advisable in

exclusive patients interest.